SuicidDentistV1, Main, Exploration, bibRecord, 000180

Periodontitis and Porphyromonas gingivalis in preclinical stage of arthritis patients.

Identifieur interne : 000180 ( Main/Exploration ); précédent : 000179; suivant : 000181

Periodontitis and Porphyromonas gingivalis in preclinical stage of arthritis patients.

Auteurs : Motomu Hashimoto [Japon] ; Toru Yamazaki [Japon] ; Masahide Hamaguchi [Japon] ; Takeshi Morimoto [Japon] ; Masashi Yamori [Japon] ; Keita Asai [Japon] ; Yu Isobe [Japon] ; Moritoshi Furu [Japon] ; Hiromu Ito [Japon] ; Takao Fujii [Japon] ; Chikashi Terao [Japon] ; Masato Mori [Japon] ; Takashi Matsuo [Japon] ; Hiroyuki Yoshitomi [Japon] ; Keiichi Yamamoto [Japon] ; Wataru Yamamoto [Japon] ; Kazuhisa Bessho [Japon] ; Tsuneyo Mimori [Japon]

Source :

PloS one [ 1932-6203 ] ; 2015.

RBID : pubmed:25849461

Descripteurs français

KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Analyse multifactorielle (MeSH), Antirhumatismaux (usage thérapeutique), Biofilms (croissance et développement), Femelle (MeSH), Humains (MeSH), Indice de gravité de la maladie (MeSH), Modèles des risques proportionnels (MeSH), Mâle (MeSH), Méthotrexate (usage thérapeutique), Parodontite (anatomopathologie), Parodontite (complications), Parodontite (microbiologie), Polyarthrite rhumatoïde (complications), Polyarthrite rhumatoïde (diagnostic), Polyarthrite rhumatoïde (traitement médicamenteux), Porphyromonas gingivalis (génétique), Porphyromonas gingivalis (isolement et purification), Porphyromonas gingivalis (physiologie), Risque (MeSH), Sujet âgé (MeSH), Études de cohortes (MeSH), Études prospectives (MeSH).
MESH :
- anatomopathologie : Parodontite.
- croissance et développement : Biofilms.
- diagnostic : Polyarthrite rhumatoïde.
- génétique : Porphyromonas gingivalis.
- isolement et purification : Porphyromonas gingivalis.
- microbiologie : Parodontite.
- physiologie : Porphyromonas gingivalis.
- traitement médicamenteux : Polyarthrite rhumatoïde.
- usage thérapeutique : Antirhumatismaux, Méthotrexate, Parodontite, Polyarthrite rhumatoïde.
- Adulte, Adulte d'âge moyen, Analyse multifactorielle, Femelle, Humains, Indice de gravité de la maladie, Modèles des risques proportionnels, Mâle, Risque, Sujet âgé, Études de cohortes, Études prospectives.

English descriptors

KwdEn :
- Adult (MeSH), Aged (MeSH), Antirheumatic Agents (therapeutic use), Arthritis, Rheumatoid (complications), Arthritis, Rheumatoid (diagnosis), Arthritis, Rheumatoid (drug therapy), Biofilms (growth & development), Cohort Studies (MeSH), Female (MeSH), Humans (MeSH), Male (MeSH), Methotrexate (therapeutic use), Middle Aged (MeSH), Multivariate Analysis (MeSH), Periodontitis (complications), Periodontitis (microbiology), Periodontitis (pathology), Porphyromonas gingivalis (genetics), Porphyromonas gingivalis (isolation & purification), Porphyromonas gingivalis (physiology), Proportional Hazards Models (MeSH), Prospective Studies (MeSH), Risk (MeSH), Severity of Illness Index (MeSH).
MESH :
- chemical , therapeutic use : Antirheumatic Agents, Methotrexate.
- complications : Arthritis, Rheumatoid, Periodontitis.
- diagnosis : Arthritis, Rheumatoid.
- drug therapy : Arthritis, Rheumatoid.
- genetics : Porphyromonas gingivalis.
- growth & development : Biofilms.
- isolation & purification : Porphyromonas gingivalis.
- microbiology : Periodontitis.
- pathology : Periodontitis.
- physiology : Porphyromonas gingivalis.
- Adult, Aged, Cohort Studies, Female, Humans, Male, Middle Aged, Multivariate Analysis, Proportional Hazards Models, Prospective Studies, Risk, Severity of Illness Index.

Abstract

PURPOSE

To determine whether the presence of periodontitis (PD) and Porphyromonas gingivalis (Pg) in the subgingival biofilm associates with the development of rheumatoid arthritis (RA) in treatment naïve preclinical stage of arthritis patients.

METHODS

We conducted a prospective cohort study of 72 consecutive patients with arthralgia who had never been treated with any anti-rheumatic drugs or glucocorticoids. Periodontal status at baseline was assessed by dentists. PD was defined stringently by the maximal probing depth≧4 mm, or by the classification by the 5th European Workshop in Periodontology (EWP) in 2005 using attachment loss. Up to eight plaque samples were obtained from each patient and the presence of Pg was determined by Taqman PCR. The patients were followed up for 2 years and introduction rate of methotrexate (MTX) treatment on the diagnosis of RA was compared in patients with or without PD or Pg.

RESULTS

Patients with PD (probing depth≧4mm) had higher arthritis activity (p = 0.02) and higher risk for future introduction of MTX treatment on the diagnosis of RA during the follow up than patients without PD (Hazard ratio 2.68, p = 0.03). Arthritis activity and risk for MTX introduction increased with the severity of PD assessed by EWP, although not statistically significant. On the other hand, presence of Pg was not associated with arthritis activity (p = 0.72) or the risk for MTX introduction (p = 0.45).

CONCLUSION

In treatment naïve arthralgia patients, PD, but not the presence of Pg, associates with arthritis activity and future requirement of MTX treatment on the diagnosis of RA.

DOI: 10.1371/journal.pone.0122121
PubMed: 25849461
PubMed Central: PMC4388350

Affiliations:

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Le document en format XML

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<author><name sortKey="Ito, Hiromu" sort="Ito, Hiromu" uniqKey="Ito H" first="Hiromu" last="Ito">Hiromu Ito</name>
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<author><name sortKey="Mori, Masato" sort="Mori, Masato" uniqKey="Mori M" first="Masato" last="Mori">Masato Mori</name>
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<author><name sortKey="Matsuo, Takashi" sort="Matsuo, Takashi" uniqKey="Matsuo T" first="Takashi" last="Matsuo">Takashi Matsuo</name>
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<author><name sortKey="Yoshitomi, Hiroyuki" sort="Yoshitomi, Hiroyuki" uniqKey="Yoshitomi H" first="Hiroyuki" last="Yoshitomi">Hiroyuki Yoshitomi</name>
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<author><name sortKey="Yamamoto, Keiichi" sort="Yamamoto, Keiichi" uniqKey="Yamamoto K" first="Keiichi" last="Yamamoto">Keiichi Yamamoto</name>
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<author><name sortKey="Yamamoto, Wataru" sort="Yamamoto, Wataru" uniqKey="Yamamoto W" first="Wataru" last="Yamamoto">Wataru Yamamoto</name>
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<author><name sortKey="Bessho, Kazuhisa" sort="Bessho, Kazuhisa" uniqKey="Bessho K" first="Kazuhisa" last="Bessho">Kazuhisa Bessho</name>
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<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea>
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<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
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<author><name sortKey="Mimori, Tsuneyo" sort="Mimori, Tsuneyo" uniqKey="Mimori T" first="Tsuneyo" last="Mimori">Tsuneyo Mimori</name>
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<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea>
<orgName type="university">Université de Kyoto</orgName>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Periodontitis and Porphyromonas gingivalis in preclinical stage of arthritis patients.</title>
<author><name sortKey="Hashimoto, Motomu" sort="Hashimoto, Motomu" uniqKey="Hashimoto M" first="Motomu" last="Hashimoto">Motomu Hashimoto</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea>
<orgName type="university">Université de Kyoto</orgName>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yamazaki, Toru" sort="Yamazaki, Toru" uniqKey="Yamazaki T" first="Toru" last="Yamazaki">Toru Yamazaki</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea>
<orgName type="university">Université de Kyoto</orgName>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hamaguchi, Masahide" sort="Hamaguchi, Masahide" uniqKey="Hamaguchi M" first="Masahide" last="Hamaguchi">Masahide Hamaguchi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morimoto, Takeshi" sort="Morimoto, Takeshi" uniqKey="Morimoto T" first="Takeshi" last="Morimoto">Takeshi Morimoto</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Hyogo</wicri:regionArea>
<wicri:noRegion>Hyogo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yamori, Masashi" sort="Yamori, Masashi" uniqKey="Yamori M" first="Masashi" last="Yamori">Masashi Yamori</name>
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<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea>
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<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Asai, Keita" sort="Asai, Keita" uniqKey="Asai K" first="Keita" last="Asai">Keita Asai</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea>
<orgName type="university">Université de Kyoto</orgName>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
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<author><name sortKey="Isobe, Yu" sort="Isobe, Yu" uniqKey="Isobe Y" first="Yu" last="Isobe">Yu Isobe</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea>
<orgName type="university">Université de Kyoto</orgName>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
</affiliation>
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<author><name sortKey="Furu, Moritoshi" sort="Furu, Moritoshi" uniqKey="Furu M" first="Moritoshi" last="Furu">Moritoshi Furu</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea>
<orgName type="university">Université de Kyoto</orgName>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
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<author><name sortKey="Ito, Hiromu" sort="Ito, Hiromu" uniqKey="Ito H" first="Hiromu" last="Ito">Hiromu Ito</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea>
<orgName type="university">Université de Kyoto</orgName>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fujii, Takao" sort="Fujii, Takao" uniqKey="Fujii T" first="Takao" last="Fujii">Takao Fujii</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea>
<orgName type="university">Université de Kyoto</orgName>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Terao, Chikashi" sort="Terao, Chikashi" uniqKey="Terao C" first="Chikashi" last="Terao">Chikashi Terao</name>
<affiliation wicri:level="4"><nlm:affiliation>Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea>
<orgName type="university">Université de Kyoto</orgName>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mori, Masato" sort="Mori, Masato" uniqKey="Mori M" first="Masato" last="Mori">Masato Mori</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea>
<orgName type="university">Université de Kyoto</orgName>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Matsuo, Takashi" sort="Matsuo, Takashi" uniqKey="Matsuo T" first="Takashi" last="Matsuo">Takashi Matsuo</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea>
<orgName type="university">Université de Kyoto</orgName>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yoshitomi, Hiroyuki" sort="Yoshitomi, Hiroyuki" uniqKey="Yoshitomi H" first="Hiroyuki" last="Yoshitomi">Hiroyuki Yoshitomi</name>
<affiliation wicri:level="4"><nlm:affiliation>Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea>
<orgName type="university">Université de Kyoto</orgName>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yamamoto, Keiichi" sort="Yamamoto, Keiichi" uniqKey="Yamamoto K" first="Keiichi" last="Yamamoto">Keiichi Yamamoto</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Epidemiology and Biostatistics, Graduate School of Medicine, Osaka University, Osaka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Clinical Epidemiology and Biostatistics, Graduate School of Medicine, Osaka University, Osaka</wicri:regionArea>
<wicri:noRegion>Osaka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yamamoto, Wataru" sort="Yamamoto, Wataru" uniqKey="Yamamoto W" first="Wataru" last="Yamamoto">Wataru Yamamoto</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Health Information Management, Kurashiki Sweet Hospital, Kurashiki, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Health Information Management, Kurashiki Sweet Hospital, Kurashiki</wicri:regionArea>
<wicri:noRegion>Kurashiki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bessho, Kazuhisa" sort="Bessho, Kazuhisa" uniqKey="Bessho K" first="Kazuhisa" last="Bessho">Kazuhisa Bessho</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea>
<orgName type="university">Université de Kyoto</orgName>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mimori, Tsuneyo" sort="Mimori, Tsuneyo" uniqKey="Mimori T" first="Tsuneyo" last="Mimori">Tsuneyo Mimori</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea>
<orgName type="university">Université de Kyoto</orgName>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PloS one</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Antirheumatic Agents (therapeutic use)</term>
<term>Arthritis, Rheumatoid (complications)</term>
<term>Arthritis, Rheumatoid (diagnosis)</term>
<term>Arthritis, Rheumatoid (drug therapy)</term>
<term>Biofilms (growth & development)</term>
<term>Cohort Studies (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Methotrexate (therapeutic use)</term>
<term>Middle Aged (MeSH)</term>
<term>Multivariate Analysis (MeSH)</term>
<term>Periodontitis (complications)</term>
<term>Periodontitis (microbiology)</term>
<term>Periodontitis (pathology)</term>
<term>Porphyromonas gingivalis (genetics)</term>
<term>Porphyromonas gingivalis (isolation & purification)</term>
<term>Porphyromonas gingivalis (physiology)</term>
<term>Proportional Hazards Models (MeSH)</term>
<term>Prospective Studies (MeSH)</term>
<term>Risk (MeSH)</term>
<term>Severity of Illness Index (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Analyse multifactorielle (MeSH)</term>
<term>Antirhumatismaux (usage thérapeutique)</term>
<term>Biofilms (croissance et développement)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
<term>Modèles des risques proportionnels (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Méthotrexate (usage thérapeutique)</term>
<term>Parodontite (anatomopathologie)</term>
<term>Parodontite (complications)</term>
<term>Parodontite (microbiologie)</term>
<term>Polyarthrite rhumatoïde (complications)</term>
<term>Polyarthrite rhumatoïde (diagnostic)</term>
<term>Polyarthrite rhumatoïde (traitement médicamenteux)</term>
<term>Porphyromonas gingivalis (génétique)</term>
<term>Porphyromonas gingivalis (isolement et purification)</term>
<term>Porphyromonas gingivalis (physiologie)</term>
<term>Risque (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Études de cohortes (MeSH)</term>
<term>Études prospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antirheumatic Agents</term>
<term>Methotrexate</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Parodontite</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Arthritis, Rheumatoid</term>
<term>Periodontitis</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Biofilms</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Arthritis, Rheumatoid</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Polyarthrite rhumatoïde</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Rheumatoid</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Porphyromonas gingivalis</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Biofilms</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Porphyromonas gingivalis</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Porphyromonas gingivalis</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Porphyromonas gingivalis</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Parodontite</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Periodontitis</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Periodontitis</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Porphyromonas gingivalis</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Porphyromonas gingivalis</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Polyarthrite rhumatoïde</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antirhumatismaux</term>
<term>Méthotrexate</term>
<term>Parodontite</term>
<term>Polyarthrite rhumatoïde</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Proportional Hazards Models</term>
<term>Prospective Studies</term>
<term>Risk</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse multifactorielle</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de gravité de la maladie</term>
<term>Modèles des risques proportionnels</term>
<term>Mâle</term>
<term>Risque</term>
<term>Sujet âgé</term>
<term>Études de cohortes</term>
<term>Études prospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>PURPOSE</b>
</p>
<p>To determine whether the presence of periodontitis (PD) and Porphyromonas gingivalis (Pg) in the subgingival biofilm associates with the development of rheumatoid arthritis (RA) in treatment naïve preclinical stage of arthritis patients.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We conducted a prospective cohort study of 72 consecutive patients with arthralgia who had never been treated with any anti-rheumatic drugs or glucocorticoids. Periodontal status at baseline was assessed by dentists. PD was defined stringently by the maximal probing depth≧4 mm, or by the classification by the 5th European Workshop in Periodontology (EWP) in 2005 using attachment loss. Up to eight plaque samples were obtained from each patient and the presence of Pg was determined by Taqman PCR. The patients were followed up for 2 years and introduction rate of methotrexate (MTX) treatment on the diagnosis of RA was compared in patients with or without PD or Pg.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Patients with PD (probing depth≧4mm) had higher arthritis activity (p = 0.02) and higher risk for future introduction of MTX treatment on the diagnosis of RA during the follow up than patients without PD (Hazard ratio 2.68, p = 0.03). Arthritis activity and risk for MTX introduction increased with the severity of PD assessed by EWP, although not statistically significant. On the other hand, presence of Pg was not associated with arthritis activity (p = 0.72) or the risk for MTX introduction (p = 0.45).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>In treatment naïve arthralgia patients, PD, but not the presence of Pg, associates with arthritis activity and future requirement of MTX treatment on the diagnosis of RA.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25849461</PMID>
<DateCompleted><Year>2015</Year>
<Month>12</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>10</Volume>
<Issue>4</Issue>
<PubDate><Year>2015</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS One</ISOAbbreviation>
</Journal>
<ArticleTitle>Periodontitis and Porphyromonas gingivalis in preclinical stage of arthritis patients.</ArticleTitle>
<Pagination><MedlinePgn>e0122121</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0122121</ELocationID>
<Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To determine whether the presence of periodontitis (PD) and Porphyromonas gingivalis (Pg) in the subgingival biofilm associates with the development of rheumatoid arthritis (RA) in treatment naïve preclinical stage of arthritis patients.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a prospective cohort study of 72 consecutive patients with arthralgia who had never been treated with any anti-rheumatic drugs or glucocorticoids. Periodontal status at baseline was assessed by dentists. PD was defined stringently by the maximal probing depth≧4 mm, or by the classification by the 5th European Workshop in Periodontology (EWP) in 2005 using attachment loss. Up to eight plaque samples were obtained from each patient and the presence of Pg was determined by Taqman PCR. The patients were followed up for 2 years and introduction rate of methotrexate (MTX) treatment on the diagnosis of RA was compared in patients with or without PD or Pg.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Patients with PD (probing depth≧4mm) had higher arthritis activity (p = 0.02) and higher risk for future introduction of MTX treatment on the diagnosis of RA during the follow up than patients without PD (Hazard ratio 2.68, p = 0.03). Arthritis activity and risk for MTX introduction increased with the severity of PD assessed by EWP, although not statistically significant. On the other hand, presence of Pg was not associated with arthritis activity (p = 0.72) or the risk for MTX introduction (p = 0.45).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In treatment naïve arthralgia patients, PD, but not the presence of Pg, associates with arthritis activity and future requirement of MTX treatment on the diagnosis of RA.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hashimoto</LastName>
<ForeName>Motomu</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yamazaki</LastName>
<ForeName>Toru</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hamaguchi</LastName>
<ForeName>Masahide</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Morimoto</LastName>
<ForeName>Takeshi</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yamori</LastName>
<ForeName>Masashi</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Asai</LastName>
<ForeName>Keita</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Isobe</LastName>
<ForeName>Yu</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Furu</LastName>
<ForeName>Moritoshi</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ito</LastName>
<ForeName>Hiromu</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fujii</LastName>
<ForeName>Takao</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Terao</LastName>
<ForeName>Chikashi</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mori</LastName>
<ForeName>Masato</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Matsuo</LastName>
<ForeName>Takashi</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yoshitomi</LastName>
<ForeName>Hiroyuki</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yamamoto</LastName>
<ForeName>Keiichi</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Epidemiology and Biostatistics, Graduate School of Medicine, Osaka University, Osaka, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yamamoto</LastName>
<ForeName>Wataru</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Health Information Management, Kurashiki Sweet Hospital, Kurashiki, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bessho</LastName>
<ForeName>Kazuhisa</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mimori</LastName>
<ForeName>Tsuneyo</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>04</Month>
<Day>07</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS One</MedlineTA>
<NlmUniqueID>101285081</NlmUniqueID>
<ISSNLinking>1932-6203</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018501">Antirheumatic Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>YL5FZ2Y5U1</RegistryNumber>
<NameOfSubstance UI="D008727">Methotrexate</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018501" MajorTopicYN="N">Antirheumatic Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001172" MajorTopicYN="N">Arthritis, Rheumatoid</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018441" MajorTopicYN="N">Biofilms</DescriptorName>
<QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008727" MajorTopicYN="N">Methotrexate</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010518" MajorTopicYN="N">Periodontitis</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016966" MajorTopicYN="N">Porphyromonas gingivalis</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016016" MajorTopicYN="N">Proportional Hazards Models</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012306" MajorTopicYN="N">Risk</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year>
<Month>11</Month>
<Day>03</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2015</Year>
<Month>02</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2015</Year>
<Month>4</Month>
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<ArticleId IdType="doi">10.1371/journal.pone.0122121</ArticleId>
<ArticleId IdType="pii">PONE-D-14-49388</ArticleId>
<ArticleId IdType="pmc">PMC4388350</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Clin Med Res. 2005 Aug;3(3):176-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16160072</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunol Rev. 2010 Jan;233(1):34-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20192991</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Rheumatol. 2011 Oct;7(10):569-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21862983</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Periodontol. 1972 Jan;43(1):38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4500182</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arthritis Rheum. 2010 Sep;62(9):2662-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20506214</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Immun. 1999 Jul;67(7):3248-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10377098</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arthritis Rheum. 2007 May;56(5):1424-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17469099</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Rheumatology (Oxford). 2014 Mar;53(3):526-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24273047</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Rheum Dis. 2011 Jan;70(1):15-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20724311</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Periodontol. 2009 Dec;36(12):1004-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19929953</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Rheum Dis. 2010 Jun;69(6):964-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20444750</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arthritis Rheum. 2010 Sep;62(9):2569-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20872595</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2013;8(3):e59341</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23555018</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Rheum Dis. 2006 Jul;65(7):905-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16284099</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Odontol Scand. 2000 Aug;58(4):183-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11045373</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arthritis Rheum. 2009 Jun;60(6):1597-603</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19479873</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Periodontol. 2005;32 Suppl 6:210-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16128839</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2010;340:c2451</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20508025</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Rheumatol. 2010 Dec;6(12):727-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20820197</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Periodontol. 2011 Nov;38(11):998-1006</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22092471</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Rheumatol. 2012 Oct;8(10):573-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22907289</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oral Dis. 2009 Jul;15(5):354-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19371397</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Circulation. 2005 Feb 8;111(5):576-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15699278</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Rheum Dis. 2011 Dec;70(12):2134-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21873689</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2013 Aug 8;500(7461):232-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23842501</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Public Health Dent. 2013 Winter;73(1):41-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23215856</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ Open. 2012 Oct 03;2(5):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23035013</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2010 Jun 7;207(6):1135-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20457757</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arthritis Res Ther. 2010;12(5):218</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21062513</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arthritis Rheum. 2012 Oct;64(10):3083-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22576262</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Rheum Dis. 2012 Sep;71(9):1541-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22875903</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Rheumatol. 2010 Jun;37(6):1105-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20436074</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Rheumatol. 2008 Jan;35(1):70-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18050377</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Intern Med. 2006 Mar 13;166(5):554-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16534043</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2010 Jun 25;32(6):815-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20620945</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Inflammation. 2004 Dec;28(6):311-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16245073</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Microbiol. 2010 Jul;8(7):481-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20514045</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arthritis Rheum. 2012 Nov;64(11):3522-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22736291</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
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	Serveur d'exploration sur le suicide chez les dentistes
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Serveur d'exploration sur le suicide chez les dentistes

Periodontitis and Porphyromonas gingivalis in preclinical stage of arthritis patients.

Periodontitis and Porphyromonas gingivalis in preclinical stage of arthritis patients.

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